Amitriptyline is a tricyclic antidepressant used for major depressive disorder and for neuropathic pain. It belongs to an older class of medicines and remains in use for both conditions. Tablets are made in four strengths, which allows the amount taken to be adjusted to the condition being treated and to how well it is tolerated.
Major Depressive Disorder, Neuropathic Pain
10 · 25 · 50 · 75mg
The amitriptyline tablets contain amitriptyline for major depressive disorder and neuropathic pain. Offered in several strengths and pack sizes. Each option lists its price per tablet.
Amitriptyline is used for major depressive disorder, where low mood can come with disturbed sleep and low energy. It is also used for neuropathic pain, the burning, shooting or electric-shock sensations that arise when nerves are damaged or irritated. One example is post-herpetic neuralgia, the burning or stabbing pain that can last for months or years after a shingles infection.
A third use is migraine prophylaxis. There the tablet is taken on a regular schedule to reduce how often attacks happen, rather than to settle an attack that has already begun. The dose and the length of treatment differ between these uses.
Amitriptyline inhibits the neuronal reuptake of serotonin and noradrenaline. Nerve cells normally take these two messengers back once a signal has travelled along them; blocking that reuptake leaves more serotonin and noradrenaline present in the central nervous system. Mood pathways and pain pathways both respond to this change in signalling, which is how one medicine can be useful in depression and in nerve pain.
The shift is gradual, so the tablet is taken on a regular schedule rather than as a one-off.
Amitriptyline is supplied as a tablet in 10 mg, 25 mg, 50 mg and 75 mg strengths, with amitriptyline as the active ingredient. Having four strengths gives some room to adjust the amount taken without moving to a different medicine, and tablets are the only form.
Orders sent to Malaysia are packed discreetly by pharmacy partners in India.
A recent myocardial infarction and heart block are both contraindications, so any heart history matters before treatment starts. Amitriptyline may impair the ability to drive, and it is worth knowing how it affects you before driving or working with machinery.
Dry mouth and drowsiness are the minor effects usually mentioned. Blurred vision, constipation and urinary retention are moderate effects. A cardiac arrhythmia is a serious effect and requires immediate medical attention.
Alcohol and MAOIs are the interactions to avoid. Older patients are treated with caution. The medicine is not recommended in pregnancy, and during breastfeeding it should be used with caution because it is excreted in milk.
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