Key points
- Fluoxetine is an SSRI, the class also described as an antidepressant.
- It blocks serotonin reuptake by neurons, raising serotonin in the synaptic cleft.
- It must not be combined with an MAO inhibitor or used by anyone hypersensitive to fluoxetine.
What fluoxetine is used for
Fluoxetine is used for major depressive disorder, obsessive-compulsive disorder and bulimia nervosa. It belongs to the antidepressant therapeutic class. Treatment is long-term, with the aim of steadying neurotransmitter activity over an extended period rather than for a short course.
How it works
Serotonin is a chemical messenger that relays signals between neurons. Fluoxetine inhibits its reabsorption into nerve cells, so more serotonin stays in the synaptic cleft. This can improve mood and reduce compulsive behaviour. Effects usually begin after two to four weeks, and use is intended for the long term.
Fluoxetine is a capsule in 10 mg, 20 mg and 60 mg strengths. Malegra FXT is a tablet containing sildenafil and fluoxetine at 100/40 mg and 100/60 mg, listed for erectile dysfunction. Both products contain fluoxetine. Delivery to Malaysia is in discreet packaging.
Before you take it
Fluoxetine must not be used by anyone with hypersensitivity to it or by anyone taking an MAO inhibitor. Children and adolescents need strict clinical monitoring. Pregnancy and breastfeeding should be discussed with a doctor or pharmacist before use. Review any liver or kidney condition and any history of seizures with a practitioner, and disclose all other medicines. Alcohol, St John’s wort and MAO inhibitors interact with fluoxetine. Other substances that affect serotonin may need to be avoided.
Side effects and warnings
Minor side effects include nausea, diarrhoea, fatigue and insomnia. Anxiety, reduced libido and tremor are moderate effects. Serotonin syndrome and suicidal ideation require immediate medical attention, and suicidal thoughts need monitoring. Fluoxetine may impair the ability to drive or operate machinery. Minor effects may settle as the body adjusts; persistent reactions need review.
Further reading