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Cataplexy Associated with Narcolepsy

Cataplexy is a sudden loss of muscle tone that affects some people with narcolepsy. It can be brief, causing weakness in the face or at the knees, or severe enough for the body to collapse. Consciousness remains intact throughout. This awareness helps distinguish cataplexy from fainting or a seizure.

Medicine used to treat Cataplexy Associated with Narcolepsy

Clomipramine

Clomipramine

10 · 25 · 50mg

Clomipramine is a tablet containing clomipramine, used for obsessive-compulsive disorder, phobic states and cataplexy linked with narcolepsy. It comes in several strengths and pack sizes. You can compare the price per tablet across options.

FromUS$0.56/ tabletView

Key points

  • A strong emotion, including laughter, surprise, anger or excitement, nearly always brings on an episode.
  • Most episodes pass in seconds or a few minutes and stop without treatment.
  • Clomipramine is a tricyclic antidepressant used to reduce how often and how severely episodes occur.

What happens during an episode

The emotional trigger is central. Laughter at a joke, a shock or the expectation of something can bring on an episode. Some people have an early sign, such as twitching in the face or drooping eyelids, before control of the muscles is lost. Episodes usually resolve on their own. Narcolepsy can go unrecognised, so cataplexy may be present for years before a diagnosis is made.

Treatment

The aim is to lower the frequency and severity of attacks. Clomipramine belongs to the antidepressants group and dampens the REM-related muscle atonia that underlies cataplexy. It has been used for this purpose for several decades. The clomipramine ingredient is supplied as tablets. It is usually taken at a low daily dose, and several weeks may pass before the full effect is seen. Orders are prepared by pharmacy partners in India and shipped to Malaysia in discreet packaging.

When to seek medical help

Involve a sleep neurologist if episodes become severe, happen often or lead to injury. They can manage it alongside any medicine being used.

Further reading

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