Key points
- Clomipramine is a tricyclic antidepressant.
- Tablets are supplied in 10 mg, 25 mg and 50 mg strengths.
- A single dose acts for about 24 hours, while the full effect takes two to four weeks.
What clomipramine is used for
Clomipramine belongs to the antidepressant group of medicines. It is used to treat obsessive-compulsive disorder and phobic states. It is also used for cataplexy associated with narcolepsy.
How it works
The medicine inhibits the reuptake of serotonin and noradrenaline at neuronal synapses. With reuptake reduced, both neurotransmitters stay available in the central nervous system for longer, which helps modulate mood and behavioural responses.
Clomipramine is supplied as a film-coated tablet in 10 mg, 25 mg and 50 mg strengths. Orders are prepared by pharmacy partners in India and shipped to Malaysia in discreet packaging.
Who should not take it
Clomipramine is contraindicated in people with hypersensitivity to it, a recent myocardial infarction, cardiac arrhythmias, severe hepatic impairment, or concurrent use of monoamine oxidase inhibitors. It should be used with caution in people with epilepsy, and suicidal thoughts need to be monitored. The medicine can impair the ability to drive or operate machinery. It is not recommended for children under 5 years. In pregnancy it should be avoided unless clearly necessary, and because small amounts pass into breast milk, clinical advice is required while breastfeeding.
Side effects and interactions
Nausea, dizziness, dry mouth, headache and constipation are among the minor effects. Sweating, tremor, weight gain, sleep disturbance and blurred vision may also occur. QT prolongation, seizures and serotonin syndrome are serious effects that require immediate medical attention. Alcohol, monoamine oxidase inhibitors, fluoxetine and cimetidine interact with clomipramine.
Further reading