Key points
- Clopidogrel is a thienopyridine antiplatelet agent, supplied as a 75mg film-coated tablet.
- A dose starts to act within about 2 hours, and the effect lasts 7 to 10 days.
- It is used to lower the risk of clot-related events after a heart attack or stroke, and in peripheral arterial disease.
What clopidogrel is used for
Clopidogrel reduces the risk of atherothrombotic events. It is prescribed for people who have had a myocardial infarction or a stroke, and for peripheral arterial disease. It belongs to the heart and blood pressure group of treatments.
How it works
Clopidogrel is a prodrug, so it has to be converted in the body before it acts. The active form blocks the P2Y12 subtype of ADP receptors on platelets, and this block is irreversible. Platelets are then less able to become activated and to aggregate, which reduces the formation of clots in the bloodstream.
Plavix 75mg film-coated tablets contain clopidogrel. Orders are shipped to Malaysia by pharmacy partners in India in discreet packaging.
Safety
Clopidogrel should not be used by anyone with hypersensitivity to it, active pathological bleeding, or severe hepatic impairment. Report any unusual bleeding, and watch for signs of bruising. Treatment is stopped before planned surgery.
Bruising, nosebleeds and diarrhoea are common. Indigestion, haematoma and gastrointestinal haemorrhage can also occur. Thrombotic thrombocytopenic purpura and intracranial haemorrhage are serious and require immediate medical attention.
Warfarin, omeprazole and aspirin can interact with clopidogrel. It is not for children. It is not recommended in pregnancy; while breastfeeding, either the medicine or breastfeeding should be stopped.
Further reading